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May 11, 2021

DRDO's drug shuts off the energy the virus receives; Find out when it will hit the market and how much it will cost

 

 DRDO's drug shuts off the energy the virus receives; Find out when it will hit the market and how much it will cost


DRDO's new drug 2-DG (2-deoxy-D-glucose) is being called a game-changer for the country to combat the second wave of corona. With the immediate approval of the Drug Controller General of India (DGCI), questions are being asked as to what is the specialty of this drug?


In fact, India has made a mistake on 4 major fronts in the fight against Corona. The first is the lack of hospital beds, the second is the lack of oxygen, the third is the shortage of medicines like remedies and the fourth is the dependence on foreign countries for the raw material of medicine or vaccines.




Corona's new drug 2-DG can improve the condition of these four fronts.

The DRDO itself says the drug will reduce patients' dependence on oxygen, plus it will take 2-3 days for them to recover, meaning patients will be discharged from the hospital sooner.


So know the pharma company Dr. How can this drug of DRDO prepared with Reddy's Laboratories help us win against Corona ...


Q. Why is this drug of DRDO being called a game changer in India's fight against Corona?


A. During the third phase of clinical trials, patients who were given DRDO drug 2-deoxy-D-glucose (2-DG) in combination with prescribed drugs, on the third day, 42% of these patients did not need oxygen as well as patients with prescribed treatment standards, i.e. standard of Medication was administered under Care (SoC), of which the figure was 31 per cent. Similarly patients who were given 2-DG medication had vital signs, i.e. heart rate (pulse rate), blood pressure, fever and respiratory rate, returned to normal only 2.5 days earlier on average compared to other patients. Patients taking the drug showed a rapid reduction in corona symptoms. So it is clear that such patients will not have to stay in hospitals for long. Similar results were seen in coronary patients over 65 years of age.


As a result, DRDO scientists say the drug will not only reduce oxygen dependence, but also alleviate the shortage of beds in hospitals. That is why 2-DG is being called a game changer.


Q. How does this drug of corona work? What is so special about it?

The drug, which is being developed in the laboratory of DRDO's Institute of Nuclear Medicine and Allied Sciences (INMAS), is a substitute for glucose. It is structurally similar to glucose, but in fact different. It is in powder form and is given to patients by mixing it in water.

The coronavirus takes glucose from the patient's body for its energy. When this drug is only deposited in infected cells. Coronavirus seems to use this drug by understanding glucose. In this way the virus stops receiving energy and its virus synthesis stops. This means that the new virus stops forming and the rest of the virus dies.


In fact, the drug was being developed to treat cancer, since it only accumulates in infected cells, and because of its properties, it was developed with the idea of ​​killing only cancerous cells. The drug is also set to be used to provide accurate chemotherapy to cancerous cells.


Q. How and in what doses can this medicine be taken?

Like normal glucose, the drug will be available in powder form in pouches. It should be mixed in water and given orally to the patient. The doctor will use the dose and time of the medicine by checking the age, medical condition etc. of the patient. DRDO scientists have also warned against taking cocaine or overdose without consulting a doctor.


Q. What will be the cost of the medicine?

The price of the drug has not been announced yet. The project director of DRDO, Dr. According to Sudhir Chandana, the price of the drug will depend on the method and quantity of the product. The industrial partner of the project, Dr. Reddy's Lab has to decide all this. The price will also be announced soon. The drug is believed to be made from generic molecules, so will not be expensive. On the other hand, citing sources, it is being claimed that the price of a pouch of medicine can be between Rs 500-600. It is believed that the government may announce some subsidies in it.


Q. With more than 4 lakh new corona patients coming up in the country every day, will this medicine be available as per the requirement?


અહીંથી વાંચો સંપુર્ણ ગુજરાતી રીપોર્ટ


Corona's drug is made from a 2-DG generic molecule, a chemical that is generic, meaning the company that developed it legally has expired the patent on its parent chemical. Generic medicine has all the qualities of a branded original medicine, although its packaging, manufacturing process, color, taste, etc. may vary. In most countries, the company that develops the original drug has a 20-year patent, so no one will be able to make the drug without the company's license. In return, they have to pay a large sum of money to a company that spends on developing the drug. Being generic, this drug can be made in large quantities at low cost.


Q. Are raw materials for making 2-DG medicine available in India or do they have to be imported?

The drug is a glucose analogue, meaning it is a glucose that is similar to a naturally occurring glucose, but is synthetically made. It is also easy to produce. The director of the project at DRDO, Dr. Sudhir Chandana said in an interview that there is no problem in the availability of raw materials. According to the information received, Dr. who is making this medicine commercially. Reddy's Lab has enough raw material.

Q. When will the drug start appearing in the market?

DRDO has hired Dr. Reddy's Lab has been made its industrial partner. The project director of DRDO, Dr. Sudhir says that DRDO is Dr. Reddy’s has tried to produce quickly with the lab. They claim that the drug could hit the market within a few days. Initially, 10,000 doses may be made available, and DRDO sources say the drug will be given to patients in about half a dozen hospitals across the country by May 11-12.


Q. Will the drug be effective for critically ill patients?

Project Direct Dr. According to Sudhir Chandana, the trial of 2-DG was performed on patients with mild, moderate and severe symptoms. All types of patients have benefited from it and no serious side effects have been reported, so this is a safe drug. The recovery rate of the patients in the second phase trial was good and the oxygen dependence of the patients in the third phase trial was less.

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Apr 25, 2021

COVID 19 New symptoms

 COVID 19 New symptoms

COVID-19 affects different people in different ways. Most infected people will develop mild to moderate illness and recover without hospitalization.

The second wave of coronavirus has spread rapidly in India. As many as 1.15 lakh new cases were registered on Tuesday. It is even higher than the peak of the first wave. The peak of the first wave was September 17, when about 97 thousand cases came up. In comparison, the second wave saw 1.03 lakh new cases on April 4 and now 1.15 lakh new cases on April 6. In addition, new symptoms are emerging as a new strain of coronavirus becomes active. Now abdominal pain, vomiting, joint pain, weakness, loss of appetite are also being considered as new symptoms of coronavirus.



Most common symptoms:

  • fever
  • dry cough
  • tiredness

Less common symptoms:

  • aches and pains
  • sore throat
  • diarrhoea
  • conjunctivitis
  • headache
  • loss of taste or smell
  • a rash on skin, or discolouration of fingers or toes


Serious symptoms:

  • difficulty breathing or shortness of breath
  • chest pain or pressure
  • loss of speech or movement
ગુજરાતી ડીટેઇલ ન્યુઝ રીપોર્ટ અહિંંથી વાંચો

ZEE ન્યુઝ રીપોર્ટ અહિંથી વાંચો 

Seek immediate medical attention if you have serious symptoms. Always call before visiting your doctor or health facility.

People with mild symptoms who are otherwise healthy should manage their symptoms at home.

On average it takes 5–6 days from when someone is infected with the virus for symptoms to show, however it can take up to 14 days.

According to the World Health Organization (WHO), different people are experiencing different symptoms. Most people are suffering from mild to moderate illness and are recovering without being hospitalized. These symptoms usually appear 5-6 days after a person becomes infected with the virus. However, in some cases these symptoms persist for up to 14 days.


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Apr 24, 2021

Snacky takatak snack on Short Videos with Top Indian App

Snacky takatak snack on Short Videos with Top Indian App

Download SnackyTakatak Application Snack on our personalized stream of videos and enjoy short, snacky, and trending viral videos! Find the best funny videos to snack on.

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Now create a duet video with your favorite team's player's video, choose from teams like KKR, Mumbai Indians, RCB, Punjab Kings, Delhi Capitals, Sunrise Hyderabad & Chennai Super Kings & be the next MX Takatak Super Star. Now snack on MX Takatak videos for funny & trending videos.

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India’s best “Made in India” SnackyTakatak short videos app to enjoy the most viral & trending snacky short videos in your own Language that you can watch anytime anywhere. SnackyTakatak lets you find & share the best snacky videos with your friends and family in seconds.
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Co-WIN app : Ministry of Health launches Co-WIN app, vaccination will be done only after registration here.

  

Co-WIN app : Ministry of Health launches Co-WIN app, vaccination will be done only after registration here.


  • The Co-WIN app app will assistance in real-time monitoring of vaccine delivery.
  • Through the app, the government will be able to keep the data of vaccinated people safe.


Image courtesy : Divya Bhaskar

The year 2021 begins with the good news of the covid vaccine. Covishield and covacin vaccines have been approved. The Co-WIN app will launching by the Union Ministry of Health to deliver the vaccine to the people. Moreover this app will help in real time monitoring of vaccine delivery. Through the app, the government will be able to keep the data of vaccinated people safe. 

Vaccination will be done after registration on this app. However, the app is currently not available on Google Play Store and Apple App Store. According to some reports, the production work of the Co-WIN app has not been completed yet. 


What is the Co-WIN app?


Co-WIN (Covid-19 Vaccine Intelligence Network) is an upgraded version of eVIN (Electronic Vaccine Intelligence Network). Once the application is completing, it will be available for free on Play Store and App Store. The Ministry of Health has clarified that corona vaccination will take place in 3 phases. 

The vaccine will giving to frontline professionals in the first phase. Moreover people involved in emergency services in the second phase. As well as people with serious conditions in the third phase.

SELF REGISTRATION FROM HERE

Registration to start on April 28

Previous reports was claiming that the registration would begin on 24th April. However, the government was now clarifying that the registration will be starting only on 28th April through the CoWIN Portal or Aarogya Setu app. Please, don’t get misguided by rumours stating that registration for vaccination of 18+ citizens to start out from April 24, 2021.

The registrations will be starting on the #CoWIN portal and Aarogya Setu App from 28th April onwards. The government of India’s official citizen engagement platform MyGovIndia tweeted that “Stay informed, Stay safe! ” 


Vaccination requires registration on the app. All users should be ready to download the app for free of charge and register themselves for a vaccine. According to media reports, the registration process will be as follows… Photo and ID are going to be required for self-registration on Co-WIN’s official website. 


Water ID, Aadhaar card, driving license, passport and pension document can be used in the ID.
Moreover mobile number has to be submitting during registration.
As soon as doing the registration, the date, time and place of vaccination will informing through SMS.


રજીસ્ટ્રેશન વિશે માહિતી ગુજરાતીમાં જાણો

5 modules of the Co-WIN app :


From this app the vaccination process will work on a platform for administrative activities. Vaccination personnel and all those who are about to be vaccinating. It includes Administrative Module, Registration Module, Vaccination Module, Beneficiary Acceptance Module and Report Module.


The people who will manage the vaccination event. Moreover they will determine the session through this module. Through it, vaccinators and providers will get information through notifications.


This module is for those who have registered in the vaccination program.



Vaccination module:

Will verify the information of people who have registered for vaccination and will also provide status update

સંપૂર્ણ સમાચાર ગુજરાતીમાં વાંચવા અહીં ક્લિક કરો.


It will send a message to the recipients of the vaccine. Moreover it will also generate a QR code. As well as people will also get an e-certificate of the vaccine. 

Report Module:

The report of the vaccination program will be preparing through it. Such as how many vaccination sessions were hold. Moreover how many people got vaccinating. As well as how many people registering but did not get vaccinated etc
Conclusion ::
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Natural Ways to Improve Oxygen Levels

 Natural Ways to Improve Oxygen Levels

Remdesivir (Veklury) was the first drug approved by the FDA for treating the SARS-CoV-2 virus. It is indicated for treatment of COVID-19 disease in hospitalized adults and children aged 12 years and older who weigh at least 40 kg. The broad-spectrum antiviral is a nucleotide analog prodrug.







 Full approval was preceded by the US FDA issuing an EUA (emergency use authorization) on May 1, 2020 to allow prescribing remdesivir for severe COVID-19 (confirmed or suspected) in hospitalized adults and children.  Upon approval of remdesivir in adults and adolescents,


How is blood oxygen level measured?
The most efficient way to monitor blood oxygen levels is by an arterial blood gas or ABG test. For this test, a blood sample is taken from an artery, usually in the wrist. This procedure is very accurate, but it can be a little painful.



An ABG test can be difficult to do at home, so a person may wish to do an alternative test, using a small device known as a pulse oximeter.

A pulse oximeter is a small clip that is often put on a finger, although it can also be used on the ear or toe. It measures blood oxygen indirectly by light absorption through a person’s pulse.

Although the pulse oximeter test is easier, quicker, and not painful, it is not as accurate as the ABG test. This is because it can be influenced by factors such as dirty fingers, bright lights, nail polish, and poor circulation to the extremities.


Low blood oxygen levels can result in abnormal circulation and cause the following symptoms:

  • shortness of breath
  • headache
  • restlessness
  • dizziness
  • rapid breathing
  • chest pain
  • confusion
  • high blood pressure
  • lack of coordination
  • visual disorders
  • sense of euphoria
  • rapid heartbeat
  • Causes


Hypoxemia, or oxygen levels below the normal values, may be caused by:

not enough oxygen in the air
inability of the lungs to inhale and send oxygen to all cells and tissues
inability of the bloodstream to circulate to the lungs, collect oxygen, and transport it around the body

Why is this medication prescribed?

Remdesivir injection is used to treat coronavirus disease 2019 (COVID-19 infection) caused by the SARS-CoV-2 virus in hospitalized adults and children 12 years of age and older who weigh at least 88 pounds (40 kg). Remdesivir is in a class of medications called antivirals. It works by stopping the virus from spreading in the body.


Remdesivir injection may cause serious reactions during and after the infusion of the medication. A doctor or nurse will monitor you carefully while you are receiving the medication. Tell your doctor or nurse immediately if you experience any of the following symptoms during or after the infusion: chills or shivering; nausea; vomiting; sweating; dizziness upon standing up; rash; wheezing or shortness of breath; abnormally fast or slow heartbeat; or swelling of the face, throat, tongue, lips, or eyes. Your doctor may need to slow down your infusion or stop your treatment if you experience these side effects.


 the EUA was updated to maintain the ability for prescribers to treat pediatric patients weighing 3.5 kg to less than 40 kg or children younger than 12 years who weigh at least 3.5 kg



Remdesivir is an investigational drug being studied to treat coronavirus infection, also known as COVID-19. It has not been approved by the FDA for general use. However, the FDA is now allowing remdesivir to be used in human studies and for emergency use in certain hospitalized patients. More information should be provided by the doctor from either the Informed Consent form for a study or the FDA Fact Sheet for Patients and Parents/Caregivers for emergency use.There is limited information known about the safety and effectiveness of using remdesivir to treat COVID-19. Some study results show that remdesivir may help some patients get better sooner. The information in this document reflects preliminary and emerging data, which is evolving and subject to reassessment. Users should be aware of these considerations in their review of investigational drug data, and it is always the responsibility of treating practitioners to exercise independent judgment in making care decisions.



How should this medicine be used?

Remdesivir comes as a solution (liquid) and as a powder to be mixed with liquid and infused (injected slowly) into a vein over 30 to 120 minutes by a doctor or nurse in a hospital. It is usually given once daily for 5 to 10 days. The length of your treatment depends on how well your body responds to the medication.

Other uses for this medicine

The FDA has approved an Emergency Use Authorization (EUA) to allow children weighing 8 pounds (3.5 kg) to less than 88 pounds (40 kg) or children less than 12 years of age weighing at least 8 pounds (3.5 kg) who are hospitalized with severe COVID-19 to receive remdesivir.




This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

ગુજરાતી ડીટેઇલ ન્યુઝ અહિંથી વાંચો

વિડીયો અહિંથી જુઓ

What special precautions should I follow?

Before receiving remdesivir,

tell your doctor and pharmacist if you are allergic to remdesivir, any other medications, or any of the ingredients in remdesivir injection. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: chloroquine or hydroxychloroquine (Plaquenil). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had liver or kidney disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

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IU -Dictionary is a FREE dictionary and translation app. Supports 58 languages.

IU -Dictionary is a FREE dictionary and translation app. Supports 58 languages.

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Protect yourself and others from COVID-19

 Protect yourself and others from COVID-19


If COVID-19 is spreading in your community, stay safe by taking some simple precautions, such as physical distancing, wearing a mask, keeping rooms well ventilated, avoiding crowds, cleaning your hands, and coughing into a bent elbow or tissue. Check local advice where you live and work. Do it all!

You also find out more about WHO's recommendations for getting vaccinated on our public advice page on COVID-19 vaccines. 


What to do if you feel unwell
Know the full range of symptoms of COVID-19. The most common symptoms of COVID-19 are fever, dry cough, and tiredness. Other symptoms that are less common and may affect some patients include loss of taste or smell, aches and pains, headache, sore throat, nasal congestion, red eyes, diarrhoea, or a skin rash.

Stay home and self-isolate even if you have minor symptoms such as cough, headache, mild fever, until you recover. Call your health care provider or hotline for advice. Have someone bring you supplies. If you need to leave your house or have someone near you, wear a medical mask to avoid infecting others.
If you have a fever, cough and difficulty breathing, seek medical attention immediately. Call by telephone first, if you can and follow the directions of your local health authority.


Keep up to date on the latest information from trusted sources, such as WHO or your local and national health authorities. Local and national authorities and public health units are best placed to advise on what people in your area should be doing to protect themselves.



What to do to keep yourself and others safe from COVID-19

Maintain at least a 1-metre distance between yourself and others to reduce your risk of infection when they cough, sneeze or speak. Maintain an even greater distance between yourself and others when indoors. The further away, the better.

Make wearing a mask a normal part of being around other people. The appropriate use, storage and cleaning or disposal are essential to make masks as effective as possible.

Here are the basics of how to wear a mask:

Clean your hands before you put your mask on, as well as before and after you take it off, and after you touch it at any time.

Make sure it covers both your nose, mouth and chin.

When you take off a mask, store it in a clean plastic bag, and every day either wash it if it’s a fabric mask, or dispose of a medical mask in a trash bin.

Don’t use masks with valves.

How to make your environment safer

Avoid the 3Cs: spaces that are closed, crowded or involve close contact.

Outbreaks have been reported in restaurants, choir practices, fitness classes, nightclubs, offices and places of worship where people have gathered, often in crowded indoor settings where they talk loudly, shout, breathe heavily or sing.

The risks of getting COVID-19 are higher in crowded and inadequately ventilated spaces where infected people spend long periods of time together in close proximity. These environments are where the virus appears to spread by respiratory droplets or aerosols more efficiently, so taking precautions is even more important.

Meet people outside. Outdoor gatherings are safer than indoor ones, particularly if indoor spaces are small and without outdoor air coming in.

For more information on how to hold events like family gatherings, children’s football games and family occasions, read our Q&A on small public gatherings.

Avoid crowded or indoor settings but if you can’t, then take precautions:

Open a window. Increase the amount of ‘natural ventilation’ when indoors.

WHO has published Q&As on ventilation and air conditioning for both the general public and people who manage public spaces and buildings.

Wear a mask (see above for more details).

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